GELMINPRAZ 1 liter

Oral suspension         

Gelminpraz contains in 1 ml as active ingredients: Praziquantel 30 mg, fenbendazole 10 mg, ivermectin 4 mg, and excipients.

The drug is manufactured in a form of a white to creamy color suspension. Suspension layering which disappears when shaken is allowed.

The drug Gelminpraz belongs to the pharmacotherapeutic group: antiparasitic agents in combinations.

Praziquantel is a synthetic derivative of isoquinoline pyrazine. Praziquantel is active against sexually mature and immature forms of tapeworms.

The mechanism of praziquantel effect is based on a violation of the permeability of the helminth membranes, damage to the outer shell, persistent depolarization of muscle cells, as well as a violation of energy metabolism, which contributes to generalized muscle contraction, turning into paralysis, and leads to the death of the parasite.

Praziquantel is well absorbed in the gastrointestinal tract, reaching a maximum concentration in blood plasma 4-6 hours after oral administration of the drug. Praziquantel undergoes biotransformation in the organism. It is excreted mainly with urine, as well as with feces, in lactating animals – partially with milk.

Fenbendazole has a wide spectrum of nematicidal activity; it is effective against all phases of the development of gastrointestinal tract and lung nematodes, including Oxyuris equi, Parascaris equorum, Delafondia vulgaris, Alfortia edentatus, Trichonema spp., Cyathostoma spp., Strongyloides spp., etc.

The mechanism of fenbendazole effect is a violation of energy processes, inhibition of tubulin polymerization of the microchannels of nematode intestinal cells, which leads to the death of the helminth.

With oral administration of the drug, fenbendazole is well absorbed in the intestine and distributed in the organs and tissues of the animal. It is excreted from the organism in unchanged form and in the form of metabolites mainly with bile and partially with urine, in lactating animals with milk.

Ivermectin is a macrocyclic lactone. It is effective against larval and mature phases of the development of gastrointestinal and pulmonary nematodes, fleas, lice, Trichodectidae, bloodsuckers, larvae of subcutaneous, nasopharyngeal and gastric gadflies, itch and gamasid mites parasitizing in pigs, cattle, and horses.

The mechanism of ivermectin effect is its effect on the amount of chlorine ion current through the membranes of nerve and muscle cells of the parasite. The main target is glutamate sensitive chlorine channels, as well as gamma-aminobutyric acid receptors. A change in the current of chlorine ions disrupts the conduction of nerve impulses, which leads to paralysis and death of the parasite.

After oral administration, ivermectin is well absorbed, enters the systemic circulation, is distributed in organs and tissues of animals, providing a long-term antiparasitic effect. Ivermectin is excreted unchanged from the organism mainly with feces and partially with urine, in lactating animals – with milk.

According to the degree of exposure to the organism, Helminthiasis refers to moderately dangerous substances. The drug is toxic to bees, as well as fish and other aquatic organisms.

Administer Gelminpraz to cattle, horses, other livestock, and poultry orally, individually or in groups without prior diet, mixed with feed or drinking water at the following doses:

cattle – 0.5 ml per 10 kg of animal weight;                    

small cattle – 0.5 ml per 10 kg of animal weight;

horses – 0.5 ml per 10 kg of animal weight;

swine – 0.5 ml per 10 kg of animal weight;

poultry – 0.1 ml per 1 kg of animal weight;

The scheme of application of the drug, depending on the type of animal and the nature of the disease, is indicated in the table:

The drug dosing regimen is indicated in the package insert and depends on the animal species and disease. Shake the canister well before each use of the drug until a homogeneous suspension is obtained.

The treatment of livestock and poultry with nematodes is carried out in the autumn before being transferred to a no–fly content and in the spring before the first walking, against gadfly infestations – immediately after the end of the gadfly summer, against arachnoentomosis pathogens - according to indications.

When applying the drug in a group way to large and small cattle, pigs and horses, a feed mixer should be used to ensure its uniform mixing with feed. In the absence of a feed mixer, the amount of the drug calculated for a group of animals is consistently mixed with portions of feed. The total amount of feed intended for mixing with the drug should not exceed half of the daily norm of its consumption by the treated livestock, according to the diet. The mixture of the drug with the feed, prepared according to the table, is laid out in feeders and provides animals with a free approach to them.

For poultry, the use of the drug is recommended to be carried out in the morning feeding. To ensure that the poultry receives the calculated dose of the drug, the supply of drinking water to the drinkers is stopped 2 hours before its use.

Before the mass treatment, pre-test each batch of the drug on a small group (3-5 heads) of animals or poultry of different ages and weights. In the absence of complications within 3 days, begin the treatment of all livestock. 

When using the drug according to the instructions for use, side effects and complications have not been established. With increased individual sensitivity of the livestock to the components of the drug and the occurrence of a sustained allergic reaction, the drug is canceled and antihistamine and symptomatic therapy is carried out.

With an overdose of the drug, the following symptoms may appear in the livestock: decreased / loss of appetite, depressed state, increased defecation and urination, excessive salivation, gastrointestinal tract disorder. In these cases, enterosorbents and symptomatic therapy are used.

Simultaneous use of the drug with other antiparasitic drugs is not allowed; with drugs containing macrocyclic lactones and piperazine; with other cholinesterase inhibitors. There is no information about the incompatibility of the drug with drugs of other pharmacological groups, feed and feed additives.

The peculiarities of the drug effect during its first use and cancellation were not revealed.

Skipping the next dose of the drug should be avoided, as this may lead to a decrease in its therapeutic effectiveness. If one dose is missed, the use of the drug is resumed as soon as possible in the same dose and according to the same scheme.

Meat slaughter is allowed:

swine: not earlier than after 21 days;

cattle and small cattle, horses, sheep, goats: – not earlier than after 28 days;

poultry: not earlier than 15 days after the last administered drug dose.

The meat of animals slaughtered compulsory before the expiration of the specified period, as well as eggs obtained before the expiration of the specified period can be used for feeding carnivorous animals. Do not consume milk within 3 days after Gelminpraz administration to animals. The milk obtained before the established period can be boiled and used for feeding animals.

The drug is toxic to bees, as well as fish and other aquatic organisms.

Gelminpraz is packaged by 1 L in polymeric canisters of appropriate capacity, sealed with tamper-evident screw caps. Each consumer package contains a package insert.

Store the drug in the original closed package, protected from direct sunlight, separately from food and feed, at a temperature of 0 to +25°C.

After opening the original package, store it at 6–8°C in a dry, dark place.

Keep out of reach of children!

It is released without a prescription from a veterinarian.

The unused drug is disposed of in accordance with the requirements of the legislation.

The shelf life under storage conditions in the original closed package is 24 months from the manufacturing date. The drug is to be used within 28 days after the first opening of the primary package.

Do not use after the expiration date.