Policefour 10% 100 ml

The drug Polycefour is produced in two dosages: Polycefour 5% and Polycefour 10%. The drug contains in 1 ml as an active ingredient: Ceftiofur hydrochloride is 50 mg and 100 mg, respectively. As excipients, the drug contains: aluminum monostearate, sorbitan oleate, benzyl alcohol, triglycerides of caprylic and capric acids. In appearance, the drug is a suspension from white to light yellow in color. During storage, stratification is allowed, which disappears after shaking. The drug Polycefour is produced packaged in 100 ml in dark glass vials of appropriate capacity, hermetically sealed with rubber stoppers reinforced with aluminum caps. The vials are individually packed in cardboard packs. Each consumer package is provided with instructions for use.

Ceftiofura hydrochloride is a semi-synthetic third-generation cephalosporin with a wide spectrum of bactericidal action on gram-negative (Escherichia coli, Pasteurella (Mannheimia) haemolytica, P. multocida, Haemophilus somnut, Haemophilus parasuis, Actinobacillus pleuropneumoniae. Salmonella choleraetuis, Salmonella typhimurium, Proteus spp., Fulbacerium necrophorum) and gram-positive (Streptococcus suis, S. zooepidemicus, S. equi, S. agalactiae, S. dysgalactiae, S. bovis, Staphylococcus spp., Actynomyces pyogenes) microorganisms, including strains producing 0 - lactamase. The mechanism of the bactericidal action of ceftiofur hydrochloride consists in inhibiting the functional activity of bacterial enzymes transpeptidases and carboxypeptidases involved in the synthesis of the main component of the cell wall of microorganisms — peptidoglycan, which leads to a violation of the osmotic balance and destruction of the bacterial cell. After parenteral administration of the drug ceftiofur hydrochloride is rapidly metabolized into desfuroyl ceftiofur, which also has an antibacterial effect. After parenteral administration of the drug, the maximum concentration of ceftiofur hydrochloride and its metabolites in blood plasma is reached 2 hours after administration and creates therapeutic concentrations in the body that persist for up to 20 hours, depending on the type of animal. The bioavailability of ceftiofur with intramuscular administration is close to 100%. Ceftiofur hydrochloride and its metabolites are excreted from the body mainly in urine (70%) and faeces (30%). The drug Polycefour, according to the degree of exposure to the body, belongs to low-hazard substances (hazard class 4 according to GOST 12.1.007-76).

Before use, the vial with the drug should be thoroughly shaken until a homogeneous suspension is obtained. The drug is administered to animals once a day. The drug Polycefour 5% is administered parenterally in the following doses: - to cattle - subcutaneously or intramuscularly at a dose of 1 ml per 50 kg of animal weight (1 mg of ceftiofur hydrochloride per 1 kg of animal weight): it should not be administered to cattle more than 15 ml, to young cattle - more than 5 ml of the drug in one place; the course of treatment for respiratory diseases is 3-5 days, for acute interdigital necrobacteriosis - 3 days, for acute postpartum endometritis and metritis (the first 10 days after childbirth), mastitis - 5 days; - small cattle (sheep and goats) - subcutaneously or intramuscularly at a dose of 0.1-0.2 ml per 5 kg of animal weight (1-2 mg of ceftiofur hydrochloride per 1 kg of animal weight); do not inject more than 5 ml of the drug in one place; the course of treatment for respiratory diseases is 3-5 days, for acute interdigital necrobacteriosis - 3 days, for acute postpartum endometritis and metritis (the first 10 days after birth), mastitis - 5 days; - pigs - intramuscularly once a day at a dose of 1 ml per 1b kg of animal weight (3 mg ceftiofur hydrochloride per 1 kg animal weight); do not inject more than 5 ml of the drug in one place; the course of treatment is 3-5 days; - horses - intramuscularly at a dose of 1 ml per 25 kg of animal weight (2 mg of ceftiofur hydrochloride per 1 kg of animal weight); do not inject more than 10 ml of the drug in one place; the course of treatment is no more than 10 days; - dogs - subcutaneously or intramuscularly at a dose of 0.3 ml per 5 kg of animal weight (3 mg of ceftiofur hydrochloride per 1 kg of animal weight); dogs should not be injected with more than 5 ml of the drug in one place; the course of treatment is no more than 10 days; - cats - subcutaneously or intramuscularly at a dose of 0.3 ml per 5 kg of animal weight (3 mg of ceftiofur hydrochloride per 1 kg of animal weight); do not inject more than 1 ml of the drug in one place; the course of treatment is no more than 10 days. The drug Polycefour 10% is administered parenterally in the following dosages: - to cattle - subcutaneously or intramuscularly at a dose of 1 ml per 100 kg of animal weight (1 mg of ceftiofur hydrochloride per 1 kg of animal weight); do not inject cattle more than 15 ml; young cattle - more than 5 ml of the drug at one time place; the course of treatment for respiratory diseases is 3-5 days, for acute interdigital necrobacteriosis - 3 days, for acute postpartum endometritis and metritis (the first 10 days after delivery), mastitis - 5 days; - pigs - intramuscularly at a dose of 1 ml per 32 kg of animal weight (3 mg ceftiofur hydrochloride per 1 kg of animal weight); do not inject more than 5 ml of the drug in one place; the course of treatment is 3-5 days; - horses - intramuscularly at a dose of 1 ml per 50 kg of animal weight (2 mg ceftiofur hydrochloride per 1 kg of animal weight): do not inject more than 10 ml of the drug in one place; the course of treatment is no more than 10 days, Injections must be done each time in a different area of the animal's body. The peculiarities of the drug's action during its first use and cancellation have not been revealed. Violations of the doses and course of use of the drug should be avoided, as this may lead to a decrease in its therapeutic effectiveness. In case of skipping one or more doses, the use of the drug is resumed in the same doses and according to the same scheme.

Side effects and complications in animals when using the drug in accordance with this instruction, as a rule, are not observed. In some animals, a local reaction may occur at the injection site in the form of edema, which spontaneously resolves within 1-2 days. In case of allergic reactions, the use of the drug is discontinued and, if necessary, desensitizing therapy is prescribed.
Contraindications: A contraindication to the use of the drug is an individual hypersensitivity of the animal to (beta-lactam antibiotics and / or other components of the drug (including in the anamnesis). The drug is prescribed with caution to animals with impaired kidney or liver function. The drug is not intended for intravenous administration.
Overdose: In case of drug overdose, the animal may experience decreased appetite, drowsiness, impaired gastrointestinal tract function, swelling at the injection site.
Interaction with other drugs: The drug should not be prescribed simultaneously with tetracyclines, chloramphenicol, macrolides and lincosamides, as well as mixed in the same syringe with other drugs. Use in pregnant and lactating animals: When using the drug during the pregnancy of an animal, the potential benefit to the mother's body and the possible risk to the fetus should be correlated. It is possible to use the drug in animals during lactation. It is forbidden to use the drug for dogs and cats under the age of 1 year.
Special instructions: Slaughter of cattle and small cattle, horses of meat breeds for meat is allowed no earlier than 8 days, pigs - no earlier than 5 days after the last use of the drug. The meat of animals forcibly killed before the expiration of the specified period can be used to feed fur-bearing animals. Milk from dairy animals during and after the use of the drug can be used for food purposes without restrictions.
Personal preventive measures: When working with a medicinal product, the general rules of personal hygiene and safety should be observed, provided for when working with medicinal products for veterinary use. People with hypersensitivity to the components of the drug should avoid direct contact with it. In case of accidental contact of the drug with the skin or mucous membranes of the eyes, they must be rinsed with plenty of water. In case of allergic reactions or accidental ingestion of the components of the drug into the human body, you should immediately contact a medical institution (have the instructions for use or label with you). Empty vials from under the drug are prohibited from being used for household purposes, they are subject to disposal with household waste.

The drug is stored in the manufacturer's closed packaging, in a place protected from direct sunlight, separate from food and feed, at a temperature from 5 °C to 25 °C. The shelf life of the drug, subject to storage conditions in the manufacturer's closed packaging, is 3 years from the date of manufacture, after opening the bottle - no more than 28 days. It is forbidden to use the drug after the expiration date. The drug should be kept out of the reach of children. Unused medicinal product is disposed of in accordance with the requirements of the legislation. The drug is released without a prescription from a veterinarian.

The shelf life of the drug, subject to storage conditions in the manufacturer's closed packaging, is 3 years from the date of manufacture, after opening the bottle - no more than 28 days.