Sinclavir powder (10 packages of 40 g)

Ingredients (in 1 g):

amoxicillin trihydrate – 575 mg (in terms of amoxicillin – 500 mg),

potassium clavulanate – 147.5 mg (in terms of clavulanic acid – 125 mg) and excipients.

In appearance, the drug is a powder from white to yellow-brown in color. The drug Synclavir powder for dogs and cats is packaged in 2.5 g, for young cattle and small cattle, foals, pigs and poultry it is packaged in 5 g, 15 g, 40 g in hermetically sealed bags made of metallized or polymer film. Packages of 2.5 g are packed in 10 pieces in cardboard packs, each pack is equipped with a syringe made of polymer materials. Packages of 5 g are packed in 9 pieces, packages of 15 g are packed in 5 pieces, packages of 40 g are packed in 1 and 10 pieces in cardboard packs. Each consumer package is provided with instructions for use. Dosage form: Powder for oral administration Pharmacotherapeutic group: Penicillins in combinations. 

Synclavir powder contains the semi-synthetic penicillin amoxicillin and the beta-lactamase inhibitor clavulanic acid. Amoxicillin in combination with clavulanic acid has a wide spectrum of antibacterial action, is active against most Gram-positive and Gram-negative microorganisms, including: Escherichia coli, Salmonella spp., Pasteurella spp., Clostridium spp., Staphylococcus spp., Erysipelothrix rhusiopathiae, Listeria monocytogenes, Bordetella spp., Haemophilus spp., Streptococcus spp., Klebsiella spp., Bacillus anthracis, Campylobacter spp., Corynebacterium spp., including beta-lactamase-producing strains. The mechanism of action of amoxicillin is to disrupt the synthesis of mucopeptide, which is part of the cell wall of microorganisms, by inhibiting the enzymes transpeptidase and carboxypeptidase, which leads to a violation of the osmotic balance and destruction of the bacterial cell. Clavulanic acid, by inhibiting β-lactamase, protects amoxicillin from destruction, which allows it to have a rapid bactericidal effect, including on penicillin-resistant microorganisms. When taken orally, amoxicillin and clavulanic acid are well absorbed from the gastrointestinal tract and penetrate into the organs and tissues of the animal body. Their maximum concentration in the blood serum is reached 1-1.5 hours after application of the drug and is maintained at the therapeutic level for at least 12 hours. Amoxicillin and clavulanic acid are excreted from the body mainly with urine and partially with bile, mainly in unchanged form. The intake of feed does not significantly affect the absorption of the drug. The drug Synclavir powder, according to the degree of exposure to the body, belongs to low-hazard substances (hazard class 4 according to GOST 12.1.007-76).

The drug is administered orally, to young cattle, small cattle, foals, dogs and cats individually, pigs and poultry individually or in a group manner. Individual regimens of the drug for farm animals and poultry: - for young cattle and small cattle, foals, the drug is used twice a day with drinking water, milk (in an amount of at least 200 ml) or feed in a single dose of 5 g per 250 kg of animal weight (equivalent to 10 amoxicillin / 2.5 mg of clavulanic acid per 1 kg of animal weight), the course of treatment is 3-5 days; - the drug is used for pigs twice a day with drinking water, milk (in an amount of at least 200 ml) or feed in a single dose of 5 g per 250 kg of animal weight (equivalent to 10 mg of amoxicillin / 2.5 mg of clavulanic acid per 1 kg of weight), the course of treatment is 3-5 days; - for agricultural poultry, the drug is used with drinking water (in an amount of at least 200 ml) at a daily dose of 5 g per 125 kg of poultry weight (equivalent to 20 mg of amoxicillin / 5 mg of clavulanic acid per 1 kg of poultry weight), the course of treatment is 3-5 days. The therapeutic solution is not subject to storage, its remains are disposed of. For group treatment of pigs and poultry, a therapeutic solution is prepared containing: for pigs - 40 g of the drug in 100 liters of water, for poultry - 15 g of the drug in 100 liters of water. It is taken into account that water consumption is approximately 10% of the weight of pigs and 20-25% of the weight of poultry. A more accurate calculation of the dose of the drug is made based on the actual consumption of water by animals on the farm. Make sure that the drug is completely dissolved in water. A fresh solution is prepared daily. The therapeutic solution should be the only source of drinking for pigs and poultry during the group treatment period. For dogs and cats, the drug is used twice a day in the form of a therapeutic solution, which is prepared immediately before application to the animal as follows: 5 ml of water measured with a syringe is added to the contents of 1 package (2.5 g of the drug) and thoroughly mixed. The resulting solution is injected into the animal using a syringe at the rate of 1 ml per 5 kg of animal weight (equivalent to 10 mg of amoxicillin / 2.5 mg of clavulanic acid per 1 kg of weight). The therapeutic solution is not subject to storage, its remains are disposed of. The drug is used for dogs and cats until recovery, but not more than 7 days. If an animal has chronic or intractable diseases, especially deep pyoderma in dogs, the course of treatment can be 14 days under the supervision of a veterinary specialist. It is allowed to use the drug in a therapeutic dose to animals that do not have clinical signs of the disease, but are in contact with sick animals, in order to prevent the spread of the disease. The peculiarities of the drug's action during its first use and cancellation have not been revealed. Violations of the doses and course of use of the drug should be avoided, as this may lead to a decrease in its therapeutic effectiveness. In case of skipping one or more doses, the use of the drug is resumed at the same dose and according to the same scheme.

Side effects and complications in animals and poultry when using the drug in accordance with this instruction, as a rule, are not observed. In case of allergic reactions, the use of the drug is discontinued and, if necessary, desensitizing therapy is prescribed.
A contraindication to the use of the drug is an individual hypersensitivity of the animal to its components (including in the anamnesis). It is prohibited to use the drug in adult ruminants with developed scar digestion, as well as laying hens whose eggs will be used for food purposes, and repair young chickens less than 2 weeks before the start of egg laying, due to the accumulation of the drug in the eggs. With caution, the drug should be used in animals with impaired renal function. 
If an animal overdoses with a drug, it may experience food withdrawal, vomiting and diarrhea. Interaction with other drugs: The drug should not be used simultaneously with other drugs of the penicillin group, tetracyclines, sulfonamides, chloramphenicol and macrolides.
Pregnancy and lactation: The possibility of using the drug during pregnancy and lactation is determined by a veterinarian based on an assessment of the ratio of potential benefit to possible risk from the use of the drug. It is allowed to use the drug in newborn animals.
Special instructions: Slaughter of young cattle and small cattle, foals and pigs for meat is allowed no earlier than 8 days, poultry - no earlier than 3 days after the last use of the drug. The meat of animals and birds that were forcibly killed before the expiration of the specified period can be used to feed fur-bearing animals.
Personal preventive measures: When working with a medicinal product, the general rules of personal hygiene and safety should be observed, provided for when working with medicinal products for veterinary use. People with hypersensitivity to the components of the drug should avoid direct contact with it. In case of accidental contact of the drug with the skin or mucous membranes of the eyes, they must be rinsed with plenty of water. In case of allergic reactions or accidental ingestion of the drug into the human body, you should immediately contact a medical institution (have the instructions for use of the drug or the label with you). It is forbidden to use an empty package from under a medicinal product for household purposes, it is subject to disposal with household waste. An unused medicinal product is disposed of in accordance with the requirements of the legislation.

The drug Synclavir powder for dogs and cats is packaged in 2.5 g, for young cattle and small cattle, foals, pigs and poultry it is packaged in 5 g, 15 g, 40 g in hermetically sealed bags made of metallized or polymer film. Packages of 2.5 g are packed in 10 pieces in cardboard packs, each pack is equipped with a syringe made of polymer materials. Packages of 5 g are packed in 9 pieces, packages of 15 g are packed in 5 pieces, packages of 40 g are packed in 1 and 10 pieces in cardboard packs. Each consumer package is provided with instructions for use.

The drug is stored in a closed manufacturer's packaging, in a place protected from direct sunlight, separate from food and feed, at a temperature from 0 ° C to 25 ° C. The shelf life of the medicinal product, subject to storage conditions in the manufacturer's closed packaging, is 2 years from the date of manufacture. After the first opening of the package, The drug should be stored at a temperature from 0 °C to 25 °C in the original packaging with the edges of the opening line well bent and fixed with a clamp for no more than 7 days. It is forbidden to use the drug after the expiration date. The drug should be kept out of the reach of children. The drug is released without a prescription from a veterinarian.

The shelf life of the drug under storage conditions in the manufacturer's closed packaging, is 2 years from the date of manufacture. After the first opening of the package, the drug should be stored at a temperature from 0 °C to 25 °C in the original packaging with the edges of the opening line well bent and fixed with a clamp for no more than 7 days.