Vetfloxacin 10 ml
Vetfloxacin is used in pigs, lambs, calves, broiler chickens, replacement chickens, and turkeys for the treatment and prevention of infectious and inflammatory diseases caused by bacteria sensitive to levofloxacin:
ü To pigs, lambs, calves for the treatment of bacterial diseases of the respiratory system, gastrointestinal tract and genitourinary system, skin and soft tissue infections, as well as for peritonitis, septicemia, spirochaetosis and mycoplasma infections.
ü To broiler chickens, replacement chickens and turkeys with colibacteriosis, dysentery, salmonellosis, pasteurellosis, necrotic enteritis, staphylococcosis, campylobacteriosis, pseudomonosis, mycoplasmosis, mixed and secondary infections with viral diseases.
Oral suspension.
Vetfloxacin contains in 1 ml as active ingredients: Levofloxacin (in the form of hemihydrate) 150 mg and excipients.
The drug is manufactured in a form of an opalescent liquid of yellow to brown color, greenish tint is also acceptable.
The drug Vetfloxacin belongs to the pharmacotherapeutic group: naphthyridine derivatives, quinolones, fluoroquinolones.
Levofloxacin in the drug formulation has a bactericidal effect on aerobic bacteria (gram-positive: Enterococcus spp., Listeria monocytogenes, Staphylococcus spp., Streptococcus spp. and gram-negative: Acinetobacter spp., Campylobacter spp., Enterobacter spp., Escherichia coli, Haemophilus ducreyi, Haemophilus influenzae, Haemophilus parainfluenzae, Klebsiella spp., Moraxella catarrhalis β+/β-, Morganella morganii, Pasteurella spp., Proteus mirabilis, Proteus vulgaris, Providencia spp., Pseudomonas spp., Salmonella spp., Serratia spp ); anaerobic bacteria: Bacteroides fragilis, Clostridium perfringens, Fusobacterium spp., Peptostreptococcus spp.; and other bacteria: Chlamydia pneumoniae, Chlamydia psittaci, Mycobacterium spp., Mycoplasma pneumoniae, Ricketsia spp..
The mechanism of levofloxacin effect is associated with the blockade of DNA gyrase (topoisomerase II) and topoisomerase IV, violation of superspiralization and crosslinking of deoxyribonucleic acid breaks, inhibition of deoxyribonucleic acid synthesis, deep metabolic changes in the cytoplasm, cell wall and membranes of bacteria.
Levofloxacin is rapidly and almost completely absorbed after oral administration. The intake of feed has little effect on the speed and completeness of absorption. The bioavailability of levofloxacin after oral administration is 99%; the concentration in the blood serum reaches a maximum 2 hours after application, the half-life is about 7 hours. It is excreted from the organism mainly by the kidneys.
Vetafloxacin, according to the degree of exposure to the organism, refers to low-risk substances.
Administer the drug orally, once a day for 3-5 days in the following doses: in calves, lambs, pigs: 0.5 ml per 10 kg of animal weight; in broiler chickens, replacement chickens, and turkeys: 5 ml per 10 liters of drinking water.
The therapeutic dose of levofloxacin for animals is 7.5 mg / kg of live weight.
During the treatment, poultry should only receive water containing the drug. The therapeutic solution is prepared daily in a volume calculated for consumption by poultry during the day.
When using the drug according to the instructions for use, side effects and complications have not been established. If a sustained allergic reaction occurs, the drug is canceled, it is recommended to conduct antihistamine and symptomatic therapy.
In case of an overdose of a drug in livestock and poultry, the following symptoms are observed: decreased/loss of appetite, depression, vomiting, diarrhea, disorientation, sometimes - tendon lesions (including tendinitis), joint and muscle pain. In these cases, it is necessary to stop using the drug. There are no specific means of detoxification, general measures aimed at removing the drug from the body and means of symptomatic therapy are used.
Simultaneous use of the drug with antacids containing magnesium and aluminum, as well as with preparations containing iron salts is not allowed due to a possible decrease in the adsorption of levofloxacin in the gastrointestinal tract of the animal.
The recommended time interval between taking the drug Vetfloxacin and the above medicines should be at least two hours.
Simultaneous use of the drug Vetfloxacin with glucocorticoids is prohibited due to an increased risk of tendinitis and / or tendon rupture, as well as nonsteroidal anti-inflammatory drugs, tetracyclines and macrolides due to an increase in the toxic effect of levofloxacin.
When used simultaneously with vitamin K antagonists, the risks of bleeding increase. Taking this into account, it is necessary to monitor coagulation indicators. It is not recommended to use the drug simultaneously with ethanol.
The peculiarities of the usage during the first application and upon cancellation of the drug were not revealed.
Skipping the next dose of the drug should be avoided, as this may lead to a decrease in therapeutic efficacy. If one dose is missed, the use of the drug is resumed as soon as possible in the same dose and according to the same scheme.
Meat slaughter of poultry is not allowed earlier than 7 days, livestock – not earlier than 10 days, the use of eggs for food purposes is not allowed earlier than 10 days after the last administered drug dose. The meat of animals slaughtered compulsory before the expiration of the specified period, as well as eggs obtained before the expiration of the specified period can be used for feeding carnivorous animals.
Contraindications to the use of the drug Vetfloxacin are increased individual sensitivity of poultry or livestock to its components and severe hepatic and / or renal insufficiency. The drug is not used for laying hens and replacement chickens, whose eggs will be used for food, less than 10 days before the start of egg laying, due to the accumulation of levofloxacin in eggs.
It is prohibited to use the drug in adult ruminants with developed cicatricial digestion and piglets weighing less than 20 kg, as well as animals with impaired development of cartilage tissue and with lesions of the nervous system accompanied by convulsions.
When using a product, the general rules of personal hygiene and safety provided for when using drugs should be observed. Smoking, drinking and eating are prohibited during the usage. At the end hands should be washed with warm water and soap. Empty packaging from under the drug is prohibited to be used for household purposes, it is subject to disposal with household waste.
People with hypersensitivity to the components of the drug should avoid direct contact with it. In case of accidental contact of the drug with the skin or mucous membranes of the eyes, they must be rinsed with plenty of water. In case of allergic reactions or accidental ingestion of the components of the drug into the human body, you should immediately contact a medical institution (take the patient information leaflet or label with you).
It is not allowed to use the drug to females during pregnancy and lactation.
Vetfloxacin is available in packages of 10 ml in polymeric vials. 10 ml vials are packed individually in cartons. Each consumer package contains a package insert.
