Levoxivet for medium and large breed dogs (10 tablets)

Levoxivet for cats and small breed dogs contains in 1 tablet as active ingredients: levofloxacin hemihydrate, equivalent to levofloxacin 250 mg and excepients: calcium stearate, lactose, microcrystalline cellulose.

The drug is made in a form of light yellow round–shaped tablet.

Levofloxacin, which is part of the drug, has a bactericidal effect on: aerobic gram-positive organisms: Enterococcus spp., Listeria monocytogenes, Staphylococcus spp., Streptococcus spp., aerobic gram-negative microorganisms: Acinetobacter spp., Campylobacter spp., Enterobacter spp., Escherichia coli, Haemophilus ducreyi, Haemophilus influenzae, Haemophilus parainfluenzae, Klebsiella spp, Moraxella catarrhalis β+/ β-, Morganella morgani, Pasteurella spp., Proteus mirabilis, Proteus vulgaris, Providencia spp., Pseudomonas spp., Salmonella spp., Serratia spp., anaerobic microorganisms: Bacteroides fragilis, Clostridium perfringens, Fusobacterium spp., Peptostreptococcus spp. and other microorganisms: Clamydia psittaci, Mycobacterium spp., Mycoplasma pneumoniae, Ricketsia spp.

The mechanism of action of levofloxacin is associated with the blockade of DNA gyrase (topoisomerase II) and topomerase IV, violation of superspiralization and crosslinking of deoxyribonucleic acid breaks, inhibition of deoxyribonucleic acid synthesis, deep metabolic changes in the cytoplasm, cell wall and membranes of bacteria. Levofloxacin is rapidly and almost completely absorbed after oral administration. The intake of feed has little effect on the speed and completeness of absorption. The bioavailability of levofloxacin after oral administration is 99%, the concentration in the blood serum reaches a maximum 2 hours after application, the half-life is about 7 hours. It is excreted from the body mainly by the kidneys.

According to the degree of exposure to the organism, Levoxivet refers to low-risk substances.

The drug Levoxivet is applied to dogs and cats orally, individually, in a fragmented form with food or forcibly injected into the root of the tongue in the form of whole, crushed or dissolved in water tablets in a daily dose:

- tablets for cats and small breed dogs– 1 tablet per 25 kg of animal weight; which corresponds to 10 mg of levofloxacin per 1 kg of animal weight.

The daily dose of the drug can be divided into 2 doses.

The duration of the course of treatment is from 3 to 7 days. If necessary, the course of treatment can be extended up to 10 days.

The peculiarities of the action during the first use of the drug or upon cancellation were not revealed.

Violations of the doses and course of use of the drug should be avoided, as this may lead to a decrease in its effectiveness. In case of missing the next use of the drug, it should be applied as soon as possible in the same dose and according to the same scheme.

Side effects and complications when using the drug in accordance with this instruction, as a rule, are not observed. In rare cases, vomiting, increased defecation and softening of feces are possible. These symptoms disappear spontaneously and do not require withdrawal of the drug. In case of allergic reactions, the use of the drug is discontinued and antihistamines and symptomatic drugs are prescribed to the pet.

Contraindications to the use of the drug are increased individual sensitivity of the animal to its components (including in the anamnesis), severe hepatic and / or renal insufficiency. It is forbidden to use the drug in pets with impaired development of cartilage tissue, with lesions of the nervous system, accompanied by convulsions.

It is forbidden to use the drug to pregnant and lactating females. It is forbidden to use the drug to large breed puppies – younger than 18 months.

In case of an overdose of the drug, the following symptoms may occur in an animal: decreased/loss of appetite, depression, vomiting, diarrhea, disorientation, sometimes - tendon damage (including tandinitis), joint and muscle pain. In these cases, it is necessary to stop using the drug. There are no specific means of detoxification, general measures aimed at removing the drug from the body and means of symptomatic therapy are used.

Simultaneous use of the drug with antacids containing magnesium and aluminum, as well as with preparations containing iron salts, is not allowed due to a possible decrease in the adsorption of levofloxacin in the gastrointestinal tract of the animal. The recommended time interval between the use of the drug Levoxivet and the above drugs should be at least 2 hours. Simultaneous use of the drug Levoxivet with glucocorticoids is prohibited due to an increased risk of tendinitis and / or tendon rupture, as well as with nonsteroidal anti–inflammatory drugs, tetracyclines and macrolides due to an increase in the toxic effect of levofloxacin. With simultaneous use of the drug with vitamin K antagonists, the risk of bleeding increases. Taking this into account, it is necessary to monitor coagulation indicators. It is not recommended to use the drug simultaneously with ethanol.

The drug is not intended for use by food-producing animals.

When using a product, the general rules of personal hygiene and safety provided for when using drugs should be observed. Smoking, drinking and eating are prohibited during the usage. Empty packaging from under the drug is prohibited to be used for household purposes, it is subject to disposal with household waste.

In case of accidental contact of the drug with the skin or mucous membranes of the eyes, they must be rinsed with plenty of water.

People with hypersensitivity to the components of the drug should avoid direct contact with it. In case of accidental contact of the drug with the skin or mucous membranes of the eyes, they must be rinsed with plenty of water. In case of allergic reactions or accidental ingestion of the components of the drug into the human body, you should immediately contact a medical institution (take the instructions for use or label with you).

Empty blisters from under the drug are prohibited from being used for household purposes, they are subject to disposal with household waste.

Unused medicinal product is disposed of in accordance with the requirements of the legislation.

The drug is produced packaged in 10 tablets in blisters, packed in cardboard packs. Each consumer package is provided with instructions for use.

Store the drug in the original closed package, protected from direct sunlight, separately from food and feed, at a temperature of 0 to +25°C.

Keep out of reach of children!

It is released without a prescription from a veterinarian.

The shelf life under storage conditions in the original closed package is 3 years from the manufacturing date.