Nefroantitox 100 g

Nefroantitox contains in 1 g as active ingredients: pyridoxine hydrochloride - 5 mg, artichoke leaf extract - 50 mg, calcium carbonate - 80 mg, and excipients: chitosan, potassium citrate, lactose.

The drug is made in a form of a cream or light brown powder, insoluble in water.

Pyridoxine hydrochloride, which is part of the drug, belongs to the group of water-soluble vitamins. It is a coenzyme of transaminases and decarboxylases, which provide amino acid metabolism and neurotransmitter synthesis. It regulates the metabolism of glutamic acid, methionine and cysteine, promotes normalization of lipid metabolism and stimulates heme synthesis in hemoglobin, increases the synthesis of iron-binding protein of the bone marrow, regulates the metabolism of vitamin B12 and folic acid; causes a slowdown in blood clotting and platelet aggregation, improves blood fluidity and blood supply to tissues.

Artichoke leaf extract stimulates the formation of bile, reduces cholesterol and urea in the blood, has hepatoprotective, antioxidant, nephroprotective, mild diuretic and hypoazotemic properties. The ascorbic acid, carotene, vitamins B1 and B2, rutin, inulin contained in the extract contribute to the normalization of metabolic processes in the body.

Calcium carbonate reduces the acidity of gastric juice, normalizes the electrolyte balance. It participates in the process of blood clotting, promotes stable heart function and normal transmission of nerve impulses. When ingested, it forms strong insoluble compounds with phosphates, thus corrects the level of calcium in the blood and helps maintain optimal phosphorus-calcium metabolism in the body. Pyridoxine hydrochloride is rapidly absorbed in the intestine, metabolized in the liver. It penetrates well into all tissues, accumulates mainly in the liver, less in the muscles and central nervous system. The half-life is 15-20 days. It is excreted mainly by the kidneys. Calcium carbonate in the stomach as a result of the interaction of the drug with gastric juice passes into a soluble form and is partially absorbed in the intestine. This process depends on the presence of vitamin D, the pH of the medium, the characteristics of the diet and the presence of factors capable of binding calcium ion. The adsorption of calcium increases with its deficiency and the use of a diet with a reduced calcium content. In plasma, about 45% of calcium is in complex with proteins. It is excreted mainly with feces. The pharmacokinetics of artichoke leaf extract has not been fully studied due to its multicomponent composition.

According to the degree of exposure to the organism, Nefroantitox refers to low-risk substances.

Nefroantitox is administered to animals orally, as a mixture of the required drug amount with food or water. A single dose of the drug is 1 g per 5 kg of animal body weight. When using the drug Nefroantitox in jars (vials), it is taken into account that 1 full large capacity of a measuring spoon without a slide corresponds to 1 g of the drug. The drug is administered twice a day, for 2-6 months, depending on the disease severity or as prescribed by a veterinarian.

The specifics of the drug's action during its first use and cancellation have not been established. Violations of the dose and course of use of the drug should be avoided, as this may lead to a decrease in its therapeutic effectiveness. In case of skipping one or more doses of the drug, the course of treatment should be resumed at the prescribed dose and the scheme of application.

Side effects and complications when using the drug in accordance with this instruction, as a rule, are not observed. With increased individual sensitivity and the appearance of allergic reactions, the use of the drug should be discontinued and, if necessary, symptomatic therapy should be prescribed to the animal.

Contraindication to the use of the drug is an individual hypersensitivity of the animal to its components (including in the anamnesis). The drug should not be used for dogs and cats younger than b months of age.

Symptoms of an overdose of the drug Nefroantitox have not been established.

The drug Nefroantitox is compatible with other medications and feed additives.

Nefroantitox can be used by animals during pregnancy and lactation.

The drug Nefroantitox is not intended for use by food-producing animals.

When using a product, the general rules of personal hygiene and safety provided for when using drugs should be observed. Smoking, drinking and eating are prohibited during the usage. Empty packaging from under the drug is prohibited to be used for household purposes, it is subject to disposal with household waste.

In case of accidental contact of the drug with the skin or mucous membranes of the eyes, they must be rinsed with plenty of water.

People with hypersensitivity to the components of the drug should avoid direct contact with it. In case of accidental contact of the drug with the skin or mucous membranes of the eyes, they must be rinsed with plenty of water. In case of allergic reactions or accidental ingestion of the components of the drug into the human body, you should immediately contact a medical institution (take the instructions for use or label with you).

The drug Nefroantitox is produced packaged in 100 g and in polymer jars (vials), hermetically sealed with lids with the control of the first opening, complete with a double-sided measuring spoon (the capacity of a larger spoon capacity is -1 g, a smaller one is 0.1 g). Cans (vials) are packed in individual cardboard packs. Each consumer package is provided with instructions for use.

Store the drug in the original closed package, protected from direct sunlight, separately from food and feed, at a temperature of 0 to +25°C.

It is released without a prescription from a veterinarian.

The unused drug is disposed of in accordance with the requirements of the legislation.

The shelf life under storage conditions in the original closed package is 3 years from the manufacturing date. Do not use after the expiration date.