Maxiclavir

Amoxicillin is a semi-synthetic antibiotic from the penicillin group. It has a wide spectrum of bactericidal activity against most Gram-positive and Gram-negative bacteria isolated from udder secretions in mastitis, including Staphylococcus spp., Streptococcus agalactiae, Streptococcus uberis, Streptococcus dysgalactiae, Corinebacterium pyogenes, Escherichia coli, Bacillus cereus, Bacteroides spp., Campylobacter spp., Klebsiella spp. and Pasteurella spp. The mechanism of antibacterial action of the antibiotic is to suppress the functional activity of bacterial enzymes transpeptidases involved in binding the main component of the cell wall of microorganisms - peptidoglycan, which leads to the death of bacteria. Clavulanic acid is a β-lactamase inhibitor structurally related to penicillins. Enhances the effect and expands the spectrum of antibacterial activity of amoxicillin, protecting the antibiotic from destruction by enzymes (β-lactamases) of microorganisms resistant to amoxicillin. Prednisone is a synthetic glucocorticosteroid. It has anti-inflammatory and anti-allergic effects, reduces swelling and inflammation. The active ingredients of the drug, when administered intracisternally, are rapidly and evenly distributed in the tissues of the breast, being absorbed into the systemic circulation to a small extent. The therapeutic concentration of the antibiotic in the breast is maintained for 12 hours. The active substances of the drug are excreted from the body of animals mainly with milk, as well as in small quantities with urine and faeces. The drug Maxiclavir, according to the degree of exposure to the body, belongs to low-hazard substances (hazard class 4 according to GOST 12.1.007-76). The drug in recommended doses does not have an irritating effect on udder tissue.

Before using the drug, milk (secret) from the diseased udder lobes is milked and disposed of, the nipple is treated with a disinfectant solution. Remove the protective cap from the tip of the syringe dispenser, insert the tip into the milk duct (partially or the entire length) and carefully squeeze out the contents of the syringe in the required amount into the affected udder lobe. Then the tip is removed from the nipple canal, the tip of the nipple is squeezed with fingers for 1-2 minutes and the nipple is lightly massaged from bottom to top for better distribution of the drug. The drug is administered to animals three times with an interval of 12 hours in single doses: cows - 3 g (1 syringe dispenser), sheep and goats - 1.5 g (half of the syringe dispenser) in each affected udder lobe. The peculiarities of the drug's action during its first use and cancellation have not been revealed. Violations of the doses and course of use of the drug should be avoided, as this may lead to a decrease in its therapeutic effectiveness. In case of skipping one or more doses, the use of the drug is resumed in the same dosages and according to the same scheme.

The drug is stored in a closed manufacturer's packaging, in a place protected from direct sunlight, separate from food and feed, at a temperature from 5 °C to 25 °C. The shelf life of the drug, subject to storage conditions in the manufacturer's closed packaging, is 2 years from the date of manufacture, after opening the syringe tube, the drug is not subject to storage. It is forbidden to use the drug after the expiration date. The drug should be kept out of the reach of children. Unused medicinal product is disposed of in accordance with the requirements of the legislation. The drug is released without a prescription from a veterinarian.

The shelf life of the drug, subject to storage conditions in the manufacturer's closed packaging, is 2 years from the date of manufacture, after opening the syringe tube, the drug is not subject to storage.