Neomastin (3 syringe tubes)

Neomycin sulfate is an antibiotic from the group of aminoglycosides. It is active against a number of gram-positive and gram-negative aerobic microorganisms: Staphylococcus spp., Streptococcus spp., Corynebacterium diphtheriae,Listeria monocytogenes, Escherichia coli, Salmonella spp., Shigella spp., Proteus spp., Enterobacter aerogenes, Klebsiellapneumoniae, Vibrio cholerae, Mycobacterium spp., Haemophilus Infuenzae. The mechanism of bactericidal action of neomycin is caused by the irreversible binding of neomycin to specific receptors of bacterial ribosomes and a violation of the synthesis of cytoplasmic membranes, which leads to the death of bacterial cells.

Amoxicillin is a semi-synthetic antibiotic from the penicillin group. It has a wide spectrum of bactericidal activity against most Gram-positive and Gram-negative microorganisms isolated from udder secretions in mastitis, including Staphylococcus spp., Streptococcus agalactiae, Streptococcus uberls, Streptococcus dysgalactiae, Corynebacterium spp.,Trueperella pyogenes, Escherichia coli, Bacillus cereus, acteroides spp., Campylobacter spp.,Klebsiella spp. and Pasteurella spp. The mechanism of antibacterial action of the antibiotic is to suppress the functional activity of bacterial enzymes of transpeptidases involved in binding the main component of the cell wall of microorganisms - peptidoglycan, which leads to the death of bacteria.

Terbinafine hydrochloride is an allylamine and has a wide range of antifungal effects. In low concentrations, it has a fungicidal effect on dermatophytes Trichophyton (T.rubrum, T.mentagrophytes, T.verrucosum, T.violaceum), Microsporum canis, Epidermophyton floccosum, mold fungi (Aspergillus, Cladosporium, Scopulariopsis brevicaulis), yeast fungi, mainly Candida albicans and some imorphic fungi. The action of yeast fungi of the genus Candida and its mycelial forms can be fungicidal or fungistatic, depending on the type of fungus. Terbinafine disrupts the early stage of biosynthesis of the main component of the fungal cell membrane (ergosterol) by inhibiting the enzyme squalene epoxidase. The active ingredients of the drug, when administered intracisternally, are rapidly and evenly distributed in the tissues of the breast, being absorbed into the systemic circulation to a small extent. The therapeutic concentration of amoxicillin in the mammary gland remains for 12 hours, neomycin and terbinafine – for 24 hours.

The active substances of the drug are excreted from the body of animals mainly with milk, and also in small quantities - with urine and feces.The drug Neomastin, according to the degree of exposure to the body, belongs to low-hazard substances (hazard class 4 according to GOST 12.1.007-76). The drug in recommended doses does not have an irritating effect on udder tissue.

Before using the drug, milk (secret) from the diseased udder lobes is milked into a separate container and disposed of, the nipple is treated with a disinfectant solution.

The protective cap is removed from the tip of the syringe tube, the tip is inserted into the milk canal (partially or completely) and the contents of the syringe tube are carefully squeezed out in the required amount. Then the tip is removed from the nipple canal, the tip of the nipple is squeezed with fingers for 1-2 minutes and the nipple is lightly massaged from bottom to top for better distribution of the drug.

During lactation, Neomastin is administered to animals 3 times, in severe cases 3-5 times with an interval of 12 hours in single doses: cows, camels, mares - 3 g (1 syringe tube), sheep and goats - 1.5 g (half of the syringe tube) in each affected udder lobe.

Neomastin is also used for therapeutic and prophylactic purposes in clinically healthy and subclinical mastitis cows immediately after the last milking before transfer to the dry period, but no later than 42 days before the expected calving. The drug is administered to animals once for 3 g (1 syringe tube) in each quarter of the udder.

The peculiarities of the drug's action during its first use and cancellation have not been revealed. Violations of the doses and course of use of the drug should be avoided, as this may lead to a decrease in its therapeutic effectiveness. In case of skipping one or more doses, the use of the drug is resumed in the same doses and according to the same scheme.

Side effects and complications in animals when using the drug in accordance with this instruction, as a rule, are not observed. With increased individual sensitivity of the animal to the components of the drug and the appearance of signs of allergy, its use is discontinued and antihistamines and symptomatic therapy are prescribed.

Contraindications:

Contraindications to the use of the drug are individual hypersensitivity of the animal to its components (including in the anamnesis), severe functional disorders of the liver and kidneys. The drug should not be used in cows less than 42 days before calving.

Overdose:

Symptoms of drug overdose in cows and small cattle have not been established.

Interaction with other drugs:

Interaction with other drugs has not been established. The drug should not be used simultaneously with other drugs for intracisternal administration.

Pregnancy and lactation:

The drug is approved for use in pregnant and lactating animals.

Special instructions:

Milk obtained from dairy animals treated with the drug during lactation may be used for food purposes no earlier than 72 hours after the last administration of the drug.

Milk obtained from cows treated with a medicinal product during the dry season is allowed to be used for food purposes no earlier than 120 hours after calving. If calving occurred earlier than the expected date, milk may be used for food no earlier than 46 days after administration of the drug. Milk from healthy udder lobes obtained earlier than the established time limits is allowed to be used in animal feed after boiling, from sick udder lobes - after disinfection it is disposed of.

Slaughter of animals for meat is allowed to be carried out no earlier than 7 days after the last administration of the drug when it is used during lactation, and no earlier than 28 days after the administration of the drug when it is used during the dry period. The meat of animals forcibly killed before the expiration of the specified period can be used to feed fur-bearing animals.

Personal prevention measures:

When working with a medicinal product, the general rules of personal hygiene and safety should be observed, provided for when working with medicinal products for veterinary use. People with hypersensitivity to the components of the drug should avoid direct contact with it. In case of accidental contact of the drug with the skin or mucous membranes of the eyes, they must be rinsed with plenty of water. In case of allergic reactions or accidental ingestion of the components of the drug into the human body, you should immediately contact a medical institution (have the instructions for use or label with you).